Three high school students find themselves drawn into a plot to turn humans into metamorphic monsters or 'Zoanoids'. Sho Fukamachi, a young boy, finds a lost 'control metal' that transforms him into the super-warrior Guyver via a mecha suit derived from alien DNA. In this bio-booster armour, Sho is nearly invincible and immortal but he must discover his powers while facing an evil corporation. With his friends Tetsuro and Mizuki and the mysterious Guyver III, Sho fights a series of Zoanoids created by the Chronos corporation that is bent on conquering the world with its army of humans that can transform into Zoanoid monsters.