Jin-Roh : The Wolf Brigade is set in a fictionalized version of the recent past, when a repressive Japanese government is battling the Sect, a violent revolutionary organization that uses adolescent girls they call 'Red Riding Hoods' as couriers. During a raid, Capitol Police Constable Kazuki Fuse balks at killing Nanami Agawa, one of the Red Riding Hoods, who then commits suicide with a powerful bomb. While Fuse undergoes retraining, he meets Nanami's older sister, Kei, and this initiates an odd romance. Soon both characters are caught in a web of plots and counterplots that center on the possibility that Fuse may be a 'wolf', a member of a secret cabal within the Capitol Police.