In 2006 a deadly virus has attacked humanity with vicious intent! At the forefront of the battle is the enigmatic Akamatsu Industries - disguised as a heavy machine factory in Tokyo, this clandestine organization uses neural enhanced weapons known as Awakeners to battle the virus. Keita Aono discovers he and his childhood friend Hinoki have the natural abilities to pilot Akamatsu Industries' giant 'neuronoid' robots. Their foe is a mysterious monster, named Algernon, whom they battle in a subterranean amusement park and their high school basement. Despite the aid of the oracular Sakura, the mecha meet with only limited success. Keita and Hinoki have to be saved by the rainbow-haired Betterman, a.k.a. 'Lamia', who transforms into an 18-foot monster that shatters foes with sonic waves. Will the combined efforts of this secret organization and the mysterious warrior Betterman be enough to save Tokyo?